NexGard Plus vs Simparica Trio: Which One is The Best for Dogs?

NexGard Plus vs Simparica Trio
FeatureNexGard PlusSimparica Trio
Protection Against FleasYesYes
Protection Against TicksYes (some types)Yes (five types)
Heartworm PreventionYesYes
Intestinal WormsYes (roundworms, hookworms)Yes (roundworms, hookworms)
Chewable FormYes (once a month)Yes (once a month)
Main Active IngredientsAfoxolaner, Milbemycin Oxime, PyrantelSarolaner, Moxidectin, Pyrantel
Tick Protection StrengthProtects against common ticksProtects against five different tick species
PriceVaries, usually comparable to Simparica TrioVaries, usually comparable to NexGard Plus
Side EffectsMild (vomiting, diarrhea, itching, lethargy)Mild (vomiting, diarrhea, lethargy)

Hello friends! Today, I’m super excited to talk about two very cool products for our dogs—NexGard Plus and Simparica Trio. If you have a dog, you probably know how important it is to protect them from parasites like fleas, ticks, and worms. These little pests can cause serious harm to your furry buddy, so keeping them safe is a big deal. But with so many products out there, it can get a bit confusing. Don’t worry, I’ve got you covered! Let’s dive into NexGard Plus vs Simparica Trio and figure out which one might be best for your pup.


What Are NexGard Plus and Simparica Trio?

Both NexGard Plus and Simparica Trio are medications designed to protect your dog from harmful parasites. They’re easy to give (they come in tasty chewable tablets), and they both work fast to keep your dog safe. But they aren’t exactly the same, so let’s break down what each one does.

NexGard Plus

NexGard Plus is a newer version of the original NexGard, which was already very popular. It protects dogs from fleas and ticks, just like the original, but with NexGard Plus, there’s an extra bonus—it also protects your dog from heartworm and intestinal worms like roundworms and hookworms. Wow, right? That’s four in one!

So, if your dog takes NexGard Plus, you’re not just keeping them safe from fleas and ticks, but you’re also keeping their insides safe from worms. That’s a huge win for both you and your dog! Plus, it’s super convenient because you only have to give it once a month.

Simparica Trio

Now, onto Simparica Trio! This is another amazing all-in-one chewable. It protects your dog from fleas, ticks, heartworm, and intestinal worms, just like NexGard Plus. But Simparica Trio has one little difference—it’s especially good at targeting five types of ticks. If you live in an area where ticks are a big problem, this could be really helpful.

Just like NexGard Plus, you give it to your dog once a month, and it starts working really fast. Your dog will be flea-free in no time! Awesome, right?


NexGard Plus vs Simparica Trio: Which One Should You Choose?

Now that you know a bit about each product, let’s dig into the big question—NexGard Plus vs Simparica Trio: Which one is better for your dog?

It all depends on your dog’s needs and where you live. Both of these chewables are great choices, but there are a few things that might make one better for your dog than the other. Let’s look at some factors that can help you decide:

1. What Parasites Are Common in Your Area?

If you live in a place where ticks are a big problem, Simparica Trio might be the better choice. This is because it covers five types of ticks, which is more than NexGard Plus. Simparica Trio is a tick-fighting superhero! On the other hand, if fleas are your biggest concern, both products will do a fantastic job.

2. Does Your Dog Have Any Special Needs?

If your dog is sensitive or allergic to certain ingredients, it’s important to check with your vet. Both NexGard Plus and Simparica Trio are safe for most dogs, but if your dog has health issues or is on other medications, your vet might have a preference.

3. Convenience and Price

Since both products are chewable tablets that you give once a month, they’re super easy to use. But when it comes to cost, one might be a little cheaper than the other. Prices can vary depending on where you buy them, so it’s always a good idea to check around and find the best deal.


Why Parasite Protection Is So Important

Before I continue comparing these two awesome products, let’s talk about why protecting your dog from parasites is so important. Fleas, ticks, and worms aren’t just annoying—they can actually cause serious health problems for your dog. Here’s what can happen if these pests get to your dog:

  • Fleas: These tiny creatures can make your dog super itchy and uncomfortable, and they can even cause allergic reactions or skin infections. Plus, fleas can carry diseases that can be passed on to humans too!
  • Ticks: Ticks are sneaky! They bite and suck blood, and in doing so, they can pass on dangerous diseases like Lyme disease and Rocky Mountain spotted fever. Not fun at all.
  • Heartworms: These are nasty parasites that live in your dog’s heart and lungs. If left untreated, heartworms can be fatal. The worst part? You might not even know your dog has heartworms until it’s too late.
  • Intestinal Worms: Roundworms, hookworms, and other types of intestinal worms can cause your dog to lose weight, vomit, or have diarrhea. In severe cases, they can be deadly.
NexGard Plus vs Simparica Trio

Scary, right? That’s why it’s so important to protect your dog from these pests. And the best way to do that is with products like NexGard Plus or Simparica Trio!


How NexGard Plus Works

So how exactly does NexGard Plus work? It’s pretty simple! After your dog eats the tasty chew, the active ingredients in the tablet get to work. The main ingredients in NexGard Plus are afoxolaner, milbemycin oxime, and pyrantel.

  • Afoxolaner: This ingredient is what kills fleas and ticks. It gets into your dog’s bloodstream and makes the fleas and ticks die when they bite your dog. It works super fast—fleas will start dying within 4 hours!
  • Milbemycin oxime: This ingredient protects against heartworms and also works against some intestinal worms like roundworms.
  • Pyrantel: This is the ingredient that takes care of hookworms and roundworms.

Together, these three ingredients give your dog complete protection from these nasty pests.


How Simparica Trio Works

Now let’s take a look at how Simparica Trio works. Just like NexGard Plus, Simparica Trio is packed with powerful ingredients that keep your dog safe. The active ingredients are sarolaner, moxidectin, and pyrantel.

  • Sarolaner: This is what kills fleas and ticks in Simparica Trio. It’s super effective and also starts working fast—fleas will be gone within 4 hours, and ticks won’t stand a chance either!
  • Moxidectin: This ingredient works against heartworms and some intestinal worms.
  • Pyrantel: Just like in NexGard Plus, pyrantel in Simparica Trio targets and kills roundworms and hookworms.

The combination of these ingredients makes Simparica Trio a super powerful weapon against fleas, ticks, heartworms, and intestinal worms.


Side Effects: Are NexGard Plus and Simparica Trio Safe?

Good news! Both NexGard Plus and Simparica Trio are generally very safe for dogs. However, just like with any medication, there can be some side effects, although they are rare.

NexGard Plus Side Effects:

Some dogs might experience mild side effects like:

  • Vomiting
  • Diarrhea
  • Itching
  • Lethargy (feeling tired)

If your dog shows any serious signs like seizures (which is very rare), it’s important to contact your vet right away.

Simparica Trio Side Effects:

Simparica Trio has similar side effects, such as:

  • Vomiting
  • Diarrhea
  • Lethargy
  • Decreased appetite

Again, serious side effects like seizures are rare, but it’s always good to keep an eye on your dog after giving them any new medication.


NexGard Plus vs Simparica Trio: Final Thoughts

So, in the battle of NexGard Plus vs Simparica Trio, which one wins? Honestly, it comes down to what your dog needs. Both products are fantastic at protecting your dog from fleas, ticks, heartworms, and intestinal worms.

  • NexGard Plus is a great choice if you want a super convenient way to protect your dog from parasites, and you don’t have a major tick problem in your area.
  • Simparica Trio is awesome if you live in a place where ticks are everywhere, and you need extra tick protection.
NexGard Plus vs Simparica Trio

Both are easy to give, highly effective, and safe for most dogs. And remember, always talk to your vet before starting your dog on any new medication. They can help you figure out which one is best for your dog’s specific needs.

FAQ: NexGard Plus vs Simparica Trio

1. What’s the difference between NexGard Plus and Simparica Trio?

Both NexGard Plus and Simparica Trio are amazing at protecting your dog from parasites, but they have some differences. NexGard Plus fights fleas, ticks, heartworms, and intestinal worms like roundworms and hookworms. On the other hand, Simparica Trio offers the same protections but is especially good at targeting five types of ticks. This makes Simparica Trio a powerful choice if you live in an area with lots of ticks. Both products are chewable tablets that are super easy to give your dog, and both work quickly to keep your pup safe.


2. Which product is better for tick protection?

If tick protection is your top priority, Simparica Trio has the upper hand! It’s designed to protect against five different types of ticks, which makes it an excellent choice for areas where ticks are a big problem. While NexGard Plus does protect against some ticks, Simparica Trio provides broader coverage, giving your dog an extra layer of safety. So, if you live in a tick-heavy region, Simparica Trio is the way to go for ultimate protection. Both options, however, ensure your dog stays happy, healthy, and pest-free!


3. Can I use NexGard Plus or Simparica Trio for puppies?

Yes! Both NexGard Plus and Simparica Trio are safe for puppies, but there are age and weight limits. NexGard Plus is approved for puppies that are at least 8 weeks old and weight at least 4 pounds. Simparica Trio can also be given to puppies that are 8 weeks old, but they need to weigh at least 2.8 pounds. Always check with your vet before giving any medication to a puppy to make sure it’s the right fit for your little furball. Ensuring early protection keeps your puppy happy and parasite-free!


4. How often do I need to give NexGard Plus or Simparica Trio to my dog?

Both NexGard Plus and Simparica Trio are incredibly convenient because you only need to give them to your dog once a month. That’s it! These chewable tablets make parasite prevention easy and hassle-free. With just one tasty chew, your dog will be protected from fleas, ticks, heartworms, and intestinal worms for a whole month. Regular use keeps your dog continuously safe, so they can enjoy their walks and playtime without worrying about parasites. Monthly doses mean easy protection for you and happy, healthy times for your dog!


5. Are NexGard Plus and Simparica Trio safe for all dogs?

Yes, NexGard Plus and Simparica Trio are both generally safe for most dogs, but like any medication, some dogs may experience mild side effects. Common side effects include vomiting, diarrhea, or lethargy, but these are rare and usually mild. If your dog has a history of seizures or any special health conditions, it’s always a good idea to discuss these with your vet before choosing a medication. Overall, both products are tested and approved for safety, meaning you can feel confident that you’re making a positive choice to protect your beloved furry friend.


6. What if my dog doesn’t like the chewable tablets?

Good news! Both NexGard Plus and Simparica Trio are made to be tasty and easy for dogs to eat. Most dogs love the flavor, so it’s unlikely your pup will turn their nose up at these chews. However, if your dog is a little picky, you can try offering it as a treat or even mixing it into their food. These chews are soft and easy to break apart if needed. Once your dog gets a taste, they’ll likely be eager to eat their monthly dose without any fuss!


7. Can I use NexGard Plus or Simparica Trio if my dog is already on other medications?

In most cases, it’s perfectly safe to give NexGard Plus or Simparica Trio alongside other medications, but it’s always best to check with your vet first. Your vet can make sure that there won’t be any interactions between your dog’s medications. Both products are well-tested and generally compatible with other treatments, so you can feel confident in using them for comprehensive protection. Your vet will help ensure your dog stays healthy, happy, and fully covered from parasites while taking any other necessary meds.


8. How fast do NexGard Plus and Simparica Trio start working?

Both NexGard Plus and Simparica Trio are fast-acting! After giving your dog the chew, fleas will start dying within 4 hours, and within a day, all the fleas should be gone. Ticks are also quickly targeted, and heartworm prevention starts immediately. The fast action means your dog will get relief from those annoying fleas and ticks in no time, keeping them comfortable and itch-free. Both products work quickly to keep parasites at bay, giving your dog the best care and protection possible with minimal waiting time!


9. How do I decide between NexGard Plus and Simparica Trio?

Deciding between NexGard Plus and Simparica Trio comes down to your dog’s specific needs. If you live in an area with a lot of different types of ticks, Simparica Trio might be the better choice due to its wide tick coverage. On the other hand, if ticks aren’t as big of an issue, NexGard Plus is also a fantastic choice, offering excellent protection against fleas, heartworms, and intestinal worms. Whichever you choose, both products provide top-notch protection for your dog. Consulting your vet will also help in making the right decision for your furry friend’s health!


10. Is it expensive to use NexGard Plus or Simparica Trio?

The prices for NexGard Plus and Simparica Trio are usually pretty comparable, and while they can vary depending on where you buy them, they’re both considered cost-effective for the comprehensive protection they offer. Considering that both of these products protect your dog from fleas, ticks, heartworms, and intestinal worms in just one chewable, they’re a great value for what they deliver. Keeping your dog safe from dangerous parasites is worth every penny, and these products make it simple and affordable to give your dog the best care possible!

At the end of the day, whichever one you choose, you’ll be doing something amazing by protecting your furry best friend from those nasty parasites. Keeping your dog healthy and happy is the ultimate goal, and both NexGard Plus and Simparica Trio are here to help you do just that!

Author

  • Alex Harper is a seasoned Product Analyst with over eight years of experience in researching and comparing consumer products across various categories. Specializing in home appliances, electronics, beauty and automotive, Alex dives deep into product specifications, user feedback, and industry trends to provide readers with honest and comprehensive reviews. When not exploring the latest gadgets, Alex enjoys attending trade shows and testing new technology firsthand.

Scroll to Top